Route 40 extends over 5000 kilometers in Argentina and unites some of the most beautiful and famous country territories. The trail crosses the Cuyo, North and Patagonia.
It passes through 11 provinces, twenty National Parks and Reserves, 13 large lakes and salt mines, and five areas declared Natural Heritage Site.
Kilometer 0 of Route 40 is the Cabo Virgenes in Santa Cruz, and it reaches its end point in the city of Jujuy Quiaca, on the border with Bolivia.
Similar feature to Route 66 in the United States, this Argentine circuit was created in 1935 and although it was not yet fully paved allows full travel with certain precautions.